Smith's Nobel Prize Lecture Highlights Process of Collaboration and Discovery | KBIA

Smith's Nobel Prize Lecture Highlights Process of Collaboration and Discovery

Dec 9, 2018

MU Professor Emeritus George Smith’s Nobel Prize lecture may have been geared toward a general audience, but it didn’t shy away from scientific detail. The crowd in the Aula Magna lecture hall on Saturday, Dec. 8, 2018, in Stockholm University was a mix of fellow laureates and their guests, students of Stockholm University and general members of the public.

“When this award was announced on October 3, my friends who are actual chemists were surprised to learn that I was one too,” Smith joked to the crowd. 

The Nobel Foundation does not award a prize in biology. Smith’s studies of phage display span disciplinary focuses, so he and Sir Gregory Winter, who share one-half of the prize, were recognized in chemistry.

Smith used the beginning of his allotted 25 minutes to thank those who assisted in the development of his research. He showed a diagram of the various types scientists of who contributed in some aspect to phage display, spanning from molecular biologists to immunologists.

“I feel that I’m accepting this award as a representative of my science community,” Smith said, “and I say ‘my science community’ because I belong to the community, not because the community belongs to me.” Smith discovered the possibility of phage display while on sabbatical at Duke University in 1985. A week later, he and his wife, MU Professor Emerita Marjorie Sable, drove back to Columbia, where he shifted the focus of his lab work and settled into his award-winning research. The rest is history. 

Smith was able to bring 14 guests to Stockholm, including some former students who worked in his lab during their graduate studies. Leslie Matthews, who did research with Smith, said the Nobel laureate is successful because of his passion and work ethic. 

“He was very organized and meticulous and very, very insistent on getting it right. That’s what I mean by scientific honesty,” Matthews said. “He would not be satisfied with anything less than 100 percent confidence in the answer. And that was a really important lesson I learned in his lab that sort of carries forth into what I do now.” 

Matthews is now an environmental biologist studying the ecological status of lakes and ponds. The work is a far cry from molecular biology, but she said Smith sculpted her understanding of what it takes to be a good scientist. “He demanded hard work, but he worked really hard himself, and it was hard not to respect him,” Matthews said. 

Jamie Scott, another guest of Smith’s, worked with him twice in her career, first while working on her doctoral degree, then again as a postdoctoral fellow. She said collaborating with Smith was gratifying because of his willingness for creative dialogue.

“Typically in the afternoon we would usually sit around, or maybe at lunch, and talk a lot about the project or what’s going on in science and come up with ideas about things and usually go, ‘no, that won’t work,’” Scott said. “That was pretty great.”

Scott said learning from Smith’s attitude toward difficulties in the lab helped her face challenges in her own research. “You just slog through it, and you make mistakes and realize that approach won’t work and you think of another,” Scott said. “That’s part of the reason why, on pretty much a daily basis, there was lots of conversation. What can you imagine you can do to get around a problem?”

Smith is quick to credit those who preceded him, as well as those who worked alongside him, but in Saturday’s lecture, he also emphasized the importance of personal insight and how their combination could lead to new discoveries including those of his co-laureate, Sir Gregory Winter.

“I think it may be a little doubtful that phage display was an invention,” Smith said. “I know that it looks like that from the outside, but from the inside, from my point of view, phage display, it was a series of small incremental advances from the knowledge that I had.”